Both Magnussen and Campbell backed up their 100m freestyle wins at the five-nation event in Perth on Friday night both romping to wins in the 50m freestyle races on Saturday.
Other Australians to shine were 17-year-old Mack Horton who won the 800m freestyle on Saturday night after also winning the 400m on Friday while Alicia Coutts took out the 100m butterfly.
Christian Sprenger also won the 50m breastroke for Australia with Leiston Pickett taking out the women's 50m breastroke, Taylor McKeown winning the 200m women's breastroke while the host nation also won both 4x100m relays and the mixed 4x100m relay to open the night.
After winning 10 of the 19 events on offer on Friday night, Australia wrapped up victory in the Aquatic Super Series winning 11 more races on Saturday to finish on a total of 629 points to win ahead of Japan (523), China (423), South Africa (332) and Brazil (230).
The first individual event of the second night of action saw South Africa's Karin Prinsloo narrowly win the 200m freestyle in a time of 1.57.41 just ahead of Australia's Bronte Barratt in 1.57.50.
The dominance of the Japanese men continued in their first event of the night with Kosuke Hagino winning the 200m freestyle also narrowly by just .23 of a second ahead of Australia's Cameron McEvoy.
Australia then got its first win of the evening in the women's 200m breastroke with McKeown scoring a relatively comfortable win ahead of Japanese pair Mio Motegi and Kanako Watanabe.
China then took out its first win of the evening thanks to Feilian Mao in the men's 200m breastroke with Australia's best being Sprenger's fourth-placing in a surprisingly low finish from the Commonwealth and Australian record holder.
Australia's Coutts then backed up her 50m butterfly win on Friday with a win in the 100m on Saturday when she won with a time of 57.60s ahead of compatriot Ellen Gandy on 58.16s.
Olympic champion from South Africa Chad le Close then comfortably won the men's 100m butterfly ahead of Australia's Chris Wright and Daniel Lester in a time of 51.06s.
Australia then won the women's 4x100m freestyle relay winning by almost eight seconds over China and South Africa with the team consisting of Bronte Campbell, Madelin Groves, McKeon and Cate Campbell bringing it home.
It was an equally dominant performance from the men in the same relay with Australia's McEvoy, Kenneth To, Magnussen and Tom D'Orsogna winning ahead of Japan in a time of 3.13.95s.
Horton then backed up his 400m freestyle win on Friday with victory in the 800m on Saturday with teammate Jessica Ashwood also winning the women's 800m.
It was then time for the sprint events starting with the women's 50m breastroke with Australia's Pickett winning ahead of fellow local Sally Hunter in a time of 31.20s.
Sprenger then made up for his fourth-placing in the 200m breastroke with a win in the 50m winning ahead of Brazil's Joao Gomes Jr in a time of 27.54s.
There was then an upset in the women's 100m backstroke with Emily Seebohm finishing third after coming second in the 50m on Friday. China's Yuanhui Fu and Japan's Sayaka Akase took up the first and second placings.
China's Jiayu Xu then won the men's 100m backstroke ahead of Japan's Ryosuke Irie with Australia's Ashley Delaney third.
Australia's sprint stars Cate Campbell and Magnussen then both backed up their 100m freestyle wins on Friday, winning the 50m races on Saturday.
Campbell won in a time of 24.21s ahead of sister Bronte (24.82s) before Magnussen won the men's race in 21.88s ahead of China's Zetao Ning and Japan's Shinri Shioura.
Japan's Miyu Otsuka then won the women's 400m individual medley before the meet concluded with the 4x100 medley relays, with Australia winning the women's and Japan the men's ahead of Australia.