Australian world No. 120 Dellacqua made sure yet another women's seed fell on Wednesday when she put on a thumping of the 18th-seed Belgian Kirsten Flipkens.
The left-handed West Australian beat Flipkens 6-3, 6-0 on Hisense Arena to win through to the third round of the Australian Open as she now looks ahead to that battle against either China's Zheng Jie on Friday after she beat American Madison Keys 7-6 (5), 1-6, 7-5.
If the 28-year-old manages to pull off that victory, it will equal her best performance in Melbourne which came about when she made the fourth round in 2008.
The next Australian woman in action on Wednesday was then the nation's No. 1 Stosur and despite having poor form leading into Melbourne, and coming up against Bulgarian Tsvetana Pironkova who was on fire, the former US Open champion put on a dominant performance.
Stosur beat an opponent who was coming off winning the Sydney International just last week and did it thumping style, 6-2, 6-0.
That now sets up a third round match-up for the 29-year-old Queenslander with former world No. 1 Ana Ivanovic.
Ivanovic entered the third round also on Wednesday night with an equally convincing victory over Germany's Annika Beck, with the 14th-seeded Serb winning 6-1, 6-2.
First up on Rod Laver Arena on Wednesday in the tough conditions was two-time former Australian Open runner-up Li Na with the Chinese 31-year-old beating Swiss teenager Belinda Bencic 6-0, 7-6 (5).
However, the 16-year-old Bencic won plenty of admirers with her second set performance on debut in Melbourne.
Serena Williams continued her ominous form already this summer having already won the Brisbane International and now dropping just three games in a thrashing on Rod Laver Arena on Wednesday of Serbia's 6-1, 6-2.
The world No. 1 and 17-time Grand Slam winner cruised into the Australian Open third round
Another seed fell on Wednesday with No. 15 German Sabine Lisicki bundled out by Romanian Monica Niculescu.
Niculescu, ranked No. 64 in the world, recovered from losing the first set to beat the Wimbledon finalist 2-6, 6-2, 6-2 on Margaret Court Arena.
Italian veteran Flavia Pennetta had a huge finish to 2013 making the US Open semi finals and she is through to the Australian Open third round after beating Portugal's Monica Puig on Wednesday.
German ninth-seed Angelique Kerber had a tough time on the opening day against Australia's Jarmila Gajdosova, but she had an easier time of things on Wednesday beating Russia's Alla Kudryavtseva 6-4, 6-2 to advance to the third round.
Russian 22nd-seed Ekaterina Makarova is into the third round as well after scoring a solid two-set victory over American Irina Falconi on Court 3, 6-2, 7-5.
Makarova and Niculescu will now battle one another in the third round.
American 23-year-old Alison Riske dropped just two games on her way to a crushing 6-1, 6-1 second round victory over Belgian Yanina Wickmayer.
The world No. 53 American will now face ninth-seeded German Kerber in the third round.
German Mona Barthel had to bounce back from losing the first set against Thailand's Luksika Kumkhum, but she did so to beat the woman who beat Petra Kvitova on Court 6, 4-6, 6-3, 6-4.
Barthel will face a tougher challenge in the third round now with a contest against Italian veteran Pennetta.
The longest battle of the day took place on Court 13 with 31st-seeded Slovak veteran Daniela Hantuchova pulling off a victory after 22 games in the third set over Czech Karolina Pliskova, 6-3, 3-6, 12-10.
And the reward for Hantuchova for prevailing in that marathon is a third round contest with world No. 1 Williams.
Lucie Safarova is also through to the Australian Open third round after beating fellow Czech Lucie Hradecka after losing the first set, 6-7 (4), 6-3, 6-0.
Safarova will now have to lift her game significantly if she hopes to make the fourth round with her set to face China's Li Na in the third round.