Chicago entertains Green Bay and Philadelphia will visit Dallas with the winner in each capturing a division crown and first-round home playoff game and the loser seeing their season conclude.
Dallas quarterback Tony Romo, who has a herniated disk in his back, is likely to be replaced by Kyle Orton when the Cowboys play host to the Philadelphia Eagles to decide the NFC East champion and a playoff spot.
Green Bay quarterback Aaron Rodgers was named on Thursday as the Packers' starter at Chicago against the team that sidelined him in a road triumph last month.
"This is a playoff game for us," Rodgers said. "It's all out there."
A victory gives the Bears or Packers the NFC North crown and spells the season's end for the loser of the NFL's oldest rivalry, which will be contested for the 188th time.
Seattle, Carolina and San Francisco have secured National Conference playoff spots with the Chicago-Green Bay and Dallas-Philadelphia winners joining them.
The sixth and final NFC spot will go to either New Orleans or Arizona.
New Orleans can clinch the berth by winning at home over Tampa Bay but anything less would allow the Cardinals to take the final wildcard berth by beating visiting San Francisco.
Seattle can seal a home-field edge throughout the path to the Super Bowl with a home win over St Louis but a loss opens the door for San Francisco to overtake them for the NFC West title.
Carolina needs a victory at Atlanta to clinch a first-round bye and the NFC South division crown.
In the American Conference, playoff spots have been clinched by division champions Denver, New England, Cincinnati and Indianapolis as well as wildcard qualifier Kansas City.
That leaves four teams - Miami, Baltimore, San Diego and Pittsburgh - vying for the last wildcard spot with all of the clubs needing help from results in other games to advance.
Miami needs a home victory over the New York Jets and either a loss by Baltimore at Cincinnati or a San Diego home victory over Kansas City to advance.
A win by reigning Super Bowl champion Baltimore would still need Miami or San Diego losing to keep the Ravens in the running to defend their crown. San Diego must win and have Baltimore and Miami lose.
Pittsburgh need a win and losses by the other three contenders to reach the playoffs.
If all four teams lose, the Ravens reach the playoffs.
Denver has clinched a first-round playoff bye, but must win at Oakland or have New England fail to beat visiting Buffalo to ensure the Peyton Manning-led Broncos have a home-field edge all the way to the Super Bowl.
Cincinnati could deny New England a first-round bye with a victory if the Patriots falter against Buffalo and Indianapolis could take the bye by beating Jacksonville if the Patriots and Cincinnati both lose.