While Cairns was coming off a win at home over Townsville on Friday night before making the long trip to Adelaide to play on Sunday, the 36ers were well rested and that showed as the game wore on.
The home team was in control of the contest from the outset, but rammed home that dominance the longer the match went to end up with a thumping 24-point victory.
The win also stops Adelaide's first two-game losing slide of the season, including a 20-point defeat in Cairns last Saturday night, and leaves the 36ers looking solid in second spot on the ladder heading into the NBL's Christmas break.
The 36ers have won the last two NBL wooden spoons as well, but currently sit on a 9-4 record to be three games behind the league-leading Perth Wildcats, but also with a two match lead over the third-placed Melbourne Tigers.
Adelaide is also the only team to have beaten Perth this season so far with a five-point win at the Adelaide Arena on November 22.
The loss for Cairns leaves the Taipans sitting on a 4-8 record in second last spot of the ladder just ahead of the three-time defending champion New Zealand Breakers.
Adelaide controlled Sunday's clash against Cairns in every facet finishing up shooting an impressive 50 per cent from the field and 42 per cent from three-point range while the Taipans managed just 37 and 17 per cent.
The 36ers also collected 42 rebounds to 36, dished out 26 assists to 18, had just eight turnovers for the entire game and finished with 46 points in the paint and 14 points off Cairns turnovers.
Big man Daniel Johnson continues to turn himself into one of the best players in the NBL with another 21 points and seven rebounds to take his season averages to 17.8 and 6.6 a game.
Captain Adam Gibson also had a good afternoon for the 36ers with 16 points and nine assists while Boomers power forward Anthony Petrie again worked hard for 13 points, six rebounds and three assists.
Centre Luke Schenscher finished with eight points and nine rebounds with import pair Gary Ervin and Jarrid Frye playing supporting roles with eight points apiece.
There was little to write home about for Cairns with Mitch Young and Cameron Gliddon the only two players to score in double-figures.
Developing big man Young finished with 11 points, five rebounds and two blocked shots while Gliddon had 10 points, three boards and two assists.
Demetri McCamey added nine points for the Snakes, Matt Burston nine, Cam Tragardh nine, Alex Loughton six and Jamar Wilson six.