Australia have named an unchanged side while England have recalled paceman Tim Bresnan for spinner Monty Panesar.
Clarke and rival captain Alastair Cook are playing their 100th Tests and have paid tribute to each other's achievements.
But their summers could hardly have been more different with Clarke posting centuries in winning sides in the first two Tests and Cook averaging just 20.50 in the series.
"To be standing here playing my 100th Test is extremely special and for Alastair as well," Clarke said on Friday.
Australia's Ryan Harris had been in some doubt for Friday's Test with an ongoing knee problem but bowled at full pace in the nets on Thursday to prove his fitness.
Clarke's men lead the five-match series two-nil and can regain the Ashes if they win in Perth.
Former Aussie quick Terry Alderman says the pitch has a green tinge and some moisture in it.
Alderman says he's expecting at least three wickets to fall in the opening session.
"It's a good toss to lose," Alderman told ABC Radio, saying he wouldn't mind having a bowl on it on Friday morning.
A top of 38 degrees is forecast and sellout crowd of over 20,000 is packing into the sun-drenched venue.
Allrounder James Faulkner's bid for a recall to the side ended in high drama as he suffered a fractured thumb while batting in the nets on Thursday.
Uncapped Western Australia quick Nathan Coulter-Nile has been named 12th man.
Australia - Michael Clarke (capt), David Warner, Chris Rogers, Shane Watson, Steve Smith, George Bailey, Brad Haddin, Peter Siddle, Mitchell Johnson, Ryan Harris, Nathan Lyon, Nathan Coulter-Nile (12th man).
England - Alastair Cook (capt), Michael Carberry, Joe Root, Kevin Pietersen, Ian Bell, Ben Stokes, Matt Prior, Tim Bresnan, Stuart Broad, Graeme Swann, James Anderson, 12th man not named.