American David Estrada, who lost on points to Mosley in Las Vegas in 2005, has been working with Mundine since early October and the 34-year-old believes the former NRL star has the size and the speed to cause real problems.
Mundine will face his toughest opponent since losing to the outstanding Danish super-middleweight Mikkel Kessler eight years ago when he climbs into the ring for the WBA light-middleweight contest at the Sydney Entertainment Centre.
Mosley has held world titles in the lightweight, welterweight and super-welterweight divisions across a glittering 20-year career.
In the 42-year-old's 56 professional fights he's won 47, lost eight and drawn one and faced some of the best boxers in a golden generation, including Floyd Mayweather, Manny Pacquiao, Miguel Cotto and Ronald 'Winky' Wright.
That quartet all outpointed the Californian and Estrada said Mundine, who at 180cm will have a six centimetre height advantage, should take encouragement from some of those losses.
"Anthony is a tall fighter and Mosley has struggled against tall guys in the past," Estrada told AAP.
"Winky Wright was similar in size and style and like Anthony had a very strong jab.
"He overpowered Mosley in their first fight and again in the rematch.
"Vernon Forrest was the same at around six foot, he also beat him twice by getting over the top of him and dominating."
Estrada concedes Mosley also has the class and the pedigree to win but said with the home crowd behind him, Mundine has a huge opportunity to cause an upset and finally earn some recognition in the US.
"The most important thing he needs to do is follow the game plan," he said.
"Do what we have worked on, keep focused and don't deviate from from that and I really believe he can win."
Estrada claims his own fight with Mosley ended in controversial circumstances.
"I was told it was 12 rounds going into the fight, but after 10 the judges made a decision in his favour," he said.
"I have watched the fight again and although I think it should have been closer on the scorecards, I am not sure I did enough to win.
"But I was the stronger fighter in the closing rounds and had it gone to 12, who knows?"
After inflicting a first defeat of classy Mexican Orlando Lora's career in 2010 with a brutal eighth-round stoppage, his progress stalled after becoming embroiled in a bitter dispute with his management team.
"I was in line for a shot at the world welterweight title, but was ill-advised and told to skip a certain fight ... they said I'd make more money if I waited," he said.
"So I waited and waited but the fights never happened. I tried I to get out of my contract but they wouldn't let me.
"It was a horrible time for me, and I had to make ends meet by working as a sparring partner as I wasn't able to fight.
"But I'm free from my contract now, won my comeback fight and excited about the future."