Thanks to 131 from Manzoor, Pakistan picked up South Africa's last two wickets early on Day 2 at Sheikh Zayed Stadium for just four runs to end the Proteas sub-par first innings at 249 with Hashim Amla not adding to his overnight score of 118.
Pakistan is now in total control after the second day of the First Test in the two-match series moving along to 3-263 at stumps on Day 2 with opening batsman Manzoor not out on 131 from 244 deliveries with 14 boundaries.
It is the first international century for the 27-year-old opener for Pakistan having previously played nine Tests and seven one-day internationals with eight half-centuries including a previous 93 against Sri Lanka in Colombo back in July 2009.
Manzoor will open Day 3 on 131 and with his captain Misbah-ul-Haq at the other end who is not out on 44 with the pair having combined already for a partnership of 85 for the fourth wicket.
South Africa struggled on the opening day after captain Graeme Smith won the toss and elected to bat first.
The Proteas slumped early to 3-43 and only Amla's 20th Test century and a fighting 57 from JP Duminy stopped them from a dismal collapse.
South Africa got to 8-245 at stumps on the opening day with Amla still at the crease not out on 118, but he fell just two balls into the second day's play when caught by Younis Khan from the bowling of 7'1 left-arm quick Mohammad Irfan.
Dale Steyn then became the final wicket to fall just 18 balls later when he was stumped by Adnan Akmal off Saeed Ajmal for 15 with Morne Morkel not out on two with South Africa making a first innings score of 249.
Pakistan's four bowlers all made a strong contribution with Irfan bouncing back from going off with cramp on Day 1 to claim 3-44 with debutant 34-year-old left-arm orthodox spinner Zulfiqar Babar claiming 3-89. Ajmal finished with 2-59 and Junaid Khan 1-52.
While Pakistan's score of 249 looked well below par, the Proteas still have the best pace bowling attack in world cricket at their disposal with Steyn, Vernon Philander, Morkel and Jacques Kallis, but they made little impact on the Pakistan batting line-up.
Openers Manzoor and Shan Masood are looking to start a new combination at the top of the innings for Pakistan and certainly made a good start to that with a 135-run opening stand before Masood fell for 75 when trapped LBW by part-time South African spinner Duminy.
Pakistan then slipped to 3-178 when Philander had Azhar Ali caught behind by AB de Villiers for 11 and the experienced Younis Khan fell to Morkel for one, but the skipper Misbah then safely partnered with Manzoor to see Pakistan through to stumps at 3-263.
Pakistan now already has a lead of 14 runs with seven first innings wickets in hand and three days of play in the United Arab Emirates still remaining in the First Test.