Kerr officially announced his retirement on Tuesday, with ongoing knee issues forcing him to call it quits despite having a year left to run on his contract.
The 30-year-old becomes the sixth Eagle to retire this year, following Adam Selwood, Mark Nicoski, Andrew Embley, Ashton Hams and Brad Dick out the door.
Kerr's exit means there are only four players remaining at West Coast from their 2006 premiership outfit - Dean Cox, Darren Glass, Beau Waters and Sam Butler.
Fellow premiership stars Quinten Lynch (Collingwood) and Chris Judd (Carlton) are still going as well, but at rival clubs.
Kerr will be remembered as one of West Coast's most courageous players.
If he wasn't getting hammered by taggers, he was getting crunched while burying into packs.
His gut running was also exceptional, but it was an asset he lost this year as his knees deteriorated.
Surgery failed to fix the issue, and Kerr told teammates of his intention to quit just days after the club's season-ending loss to Adelaide in August.
"I've been lucky to be able to wake up every day and do what I love, but lately it has become harder to get my body to carry out my mind's instructions," said Kerr, who managed just 10 games this season.
"It was hard to come to terms with the fact that I probably wasn't going to be able to play to the standard that I wanted, but I recognise that my best football is past me and it's time to step aside to let the new generation through.
"I've had the time of my life at this football club and I've made friends that I'll keep until the end of my days."
Kerr only ever won one All-Australian guernsey - in 2007 - and never won a club best and fairest.
But he regularly caught the eye of the umpires when it came to the Brownlow medal.
The 220-game veteran finished second in the 2005 Brownlow count behind Ben Cousins, and finished third in 2006 and equal second in 2007 despite being ineligible to win in both seasons.
In West Coast's premiership year of 2006, Kerr joined forces with Judd and Cousins to create the most formidable midfield in the league.
The nuggety rover was caught up in West Coast's infamous off-field issues last decade.
But following Cousins' departure at the end of 2007, Kerr cleaned up his act to become a key leadership figure as West Coast rejuvenated their list.
Although the Eagles finished a lowly 13th this season, they have been tipped to bounce straight back into the finals next season under new coach Adam Simpson.
Former coach John Worsfold, who announced his retirement last month, has been helping the club in its transition to a new coach.
ALL YOU NEED TO KNOW ABOUT DANIEL KERR'S AFL CAREER:
*Runner-up in 2005 Brownlow medal count
*Premiership player 2006