The 31-year-old won her fifth US Open title by securing the victory over the Belarusian in her second straight title in New York after also beating Azarenka in the final last year.
The world No. 1 has now not only won the five US Open titles at Flushing Meadows, but also five Australian Opens, two titles at Roland Garros and five Wimbledon championships to give her 17 Grand Slams titles while showing no signs whatsoever of slowing down or losing her hunger.
Not only has Williams won 17 major singles, but also 13 doubles championships with her older sister Venus to go with 55 titles overall on the WTA Tour, an Olympic gold medal from 2012 in singles, and also winning gold in doubles in 2000, 2008 and 2012.
While there is still Steffi Graf, Martina Navratilova, Chris Evert, Margaret Court and Billie Jean King in the discussion along with Williams in regards to the greatest women's player off all-time, the American is still building on her achievements.
And even though it was the second time in 12 months that Azarenka has lost to Williams in a final in New York, at just 24 years of age and already having two major wins to her credit, there's no doubt she is on track to put together an outstanding career herself.
While the final result of the 2013 US Open might have gone as most expected, it was a thrilling final that Williams had to battle through against Azarenka.
Williams won the first set 7-5 but it took 58 minutes with precious little separating the world's top two ranked players. It was only when the American broke Azarenka's serve in 12th game that she was able to go up one set to love.
It was an even tighter battle in the second set with it lasting 70 minutes before being decided in the tie-break with Azarenka winning that eight points to six.
Both players broke the other's serve three times during the set and even though Williams won more points overall in the set and served for the match twice, Azarenka won the points that mattered in the tie-breaker to force a deciding third set.
Despite the first two sets being such evenly contested battles, it was all Williams in the third as she won it in just 37 minutes six games to go one while Azarenka managed just two winners opposed to eight unforced errors, hit two double faults and didn’t create a single break point.
In the end, Williams won 7-5, 6-7 (6), 6-1 to claim the 2013 US Open after previously winning in New York in 1999, 2002, 2008 and 2012.
Williams went right through the tournament without dropping a single set until the final despite coming up against some talented opponents including Francesca Schiavone, Yaroslava Shvedova, Sloane Stephens, Carla Suarez Navarro and Li Na along the way.
The American now only gives her 2013 a pass mark having won the US Open and at Roland Garros but only making the quarter finals at the Australian Open and fourth round at Wimbledon.
She continues to have the drive to keep going as she tries to continue to knock off milestone after milestone.
"There's always pressure to defend your title but I didn’t feel a lot of pressure. I knew I want to win, but losing a match before I got to the Open actually took a little bit of the pressure that was on me off me so it actually made it a little bit better," Williams said.
"I'm excited about the possibilities of what I can still achieve and I don’t know what can happen, but to be honest before coming here I felt almost disappointed with my year.
"I won the French Open but I wasn’t happy with my performances in the other two Slams, especially not to make the quarter finals of one. So I definitely feel a lot better with at least a second Grand Slam under my belt this year."
Over the last two years and eight Grand Slam tournaments, Azarenka has now won two of them, made the final in another two, made two more semi-finals and only bombed out in one fourth round and one second round.
That showed that she is consistent and deserves to be the second best player in the world behind Williams at present and she is taking the positives out of the loss to Williams.
"It's different and I will not think of how tough this loss is going to reflect on me compared to last year's. I'm just going to take the best out of what happened today because are a lot of positive things," Azarenka said.
"What's negative is the result but to take a look overall, to see how much you rise to the occasion compare to the other matches, I think it's pretty remarkable.
"The challenge that is in front of me is only going to make me more motivated and we showed today that the women's game is really, really competitive."