While Hantuchova, Pennetta and Vinci can all rest easy now on Tuesday awaiting their quarter-final match-ups at Flushing Meadows on Wednesday, the final fourth round clash still needs to be played between former world No. 1s Ana Ivanovic and Victoria Azarenka.
The New York weather again meant that a full day's play wasn’t able to be completed but it didn’t stop three enthralling women's fourth round matches taking place.
The only one of the three that went to three sets was between Slovak 30-year-old Hantuchova and rising American Alison Riske.
Riske was in the first fourth round Grand Slam appearance of her career and Hantuchova her first since Roland Garros in 2011 so both were already having a breakthrough week at the US Open.
The experience of Hantuchova told in the first set, though, with her taking it out 6-3 but the 23-year-old American who is ranked 81st in the world wouldn’t go away and levelled things up at a set apiece.
However, in the end Hantuchova's bigger all-round game saw her get over the line 6-3, 5-7, 6-2 as she finished the match with a supremely impressive 15 aces and 46 winners as opposed to just two double-faults and 22 unforced errors.
Hantuchova was also able to break Riske's serve four times from seven opportunities to now advance to her first Grand Slam quarter-final since she reached the semis of the 2008 Australian Open.
The Slovak world No. 48, who did reach as high as 5 in the world 11 years ago, will now face the winner of Tuesday's held over fourth round clash between Ivanovic and Azarenka.
She has only won two of her seven career meetings against Ivanovic but is 2-2 with Azarenka even though the Belarusian world No. 2 has won their last two meetings.
Italian veterans Pennetta and Vinci will now meet one another in the quarter finals after the pair won their fourth round matches on Monday in straight-sets.
Pennetta had a decidedly tougher time of it but she also had an opponent with more credentials on the big stage when she took on Romanian No. 21 seed Simona Halep.
The 31-year-old Pennetta comfortably won the first set but then Halep lifted a gear in the second to force it to a tie-break, but the Italian prevailed to win the match 6-2, 7-6 (3).
It continues a strong resurgence for Pennetta with the 83rd-ranked Italian having a horror 2012 where she finished the year out of the top 40 for the first time in nine years and required wrist surgery after forfeiting at the US Open.
However, she is back playing terrific tennis to set up her quarter-final clash with Vinci.
The No. 10 seed had little trouble beating another Italian Camila Giorgi who didn’t handle her first Grand Slam fourth round appearance all that well.
Giorgi hit seven double-faults and won just 11 of 37 points on her second serve while also having 35 unforced errors in a forgettable match for the 21-year-old.
It wasn’t forgettable for Vinci, though, as she won 6-4, 6-2 to set up the ninth career meeting between her and Pennetta with them so far having split them with four wins apiece.
Remarkably, though, the Italians haven’t faced one another on the WTA Tour since Pennetta won 6-1, 6-1 at the 2010 French Open.
The women's quarter finals will then get underway on Arthur Ashe Stadium on Tuesday after the fourth round clash with Ivanovic and Azarenka is completed.
First-up is the fifth-seed from China Li Na taking on Russian 24th-seed Ekaterina Makarova before the night session begins with world No. 1 Serena Williams battling 18th-seeded Spanish veteran Carla Suarez Navarro.