It is a star-studded opening to the first day of the final Grand Slam of 2013 with a host of top-seeds and former major winners all in action.
Australia will be well represented on the opening day with Tomic, Nick Kyrgios, Ashleigh Barty and Marinko Matosevic all involved in singles action.
Tomic will be disappointed to have had his controversial father John denied accreditation to the tournament, but he will have to put that out of his mind when the 20-year-old world No. 52 takes on experienced and talented Spaniard Albert Ramos in the first match on the Grandstand court.
Kyrgios faces a massive task up against world No. 4 David Ferrer who is coming off making the French Open final as the 18-year-old Australian in his first US Open main draw appearance.
Barty is one of Australia's brightest young stars and already has done well at Grand Slam level in doubles action alongside Casey Dellacqua, and she will be looking to begin really making her mark in singles when the 17-year-old takes on Spaniard world No. 102 Estrella Cabeza Candela.
Australia's fourth participant on the opening day is Matosevic and he faces a big task up against Spanish veteran and No. 19 seed Tommy Robredo who is coming off a quarter-final appearance at the French Open earlier in 2013.
The highlights of the men's action on the opening day includes Nadal, Federer, Fernando Verdasco, Nikolay Davydenko, Richard Gasquet, Kei Nishikori and Janko Tipsarevic being in action.
The first men's match on Arthur Ashe Stadium pits world No. 2 Nadal up against American Ryan Harrison as the Spaniard vies for another US Open crown and the resultant No. 1 world ranking that would come his way if he is victorious.
The night men's clash on Arthur Ashe sees Federer, who has slipped to No. 7 in the world, begin his US Open campaign up against Slovakia's Grega Zemlja.
Frenchman world No. 8 Gasquet is ikn action on Louis Armstrong Stadium when he comes up against another talented American Michael Russell.
Following Tomic's match with Ramos on the Grandstand court, Spanish No. 27 seed Verdasco comes up against Croatia's Ivan Dodig.
Another talented Spaniard, Feliciano Lopez, takes on Florent Serra from France on Court 6 while Russian veteran Davydenko takes on American Rhyne Williams in what could be his last Grand Slam tournament.
Japan's Nishikori has continued to come along throughout 2013 as a rising star in the game and he kicks off his US Open campaign up against Briton Daniel Evans on Court 13.
Serbia's No. 18 seed Tipsarevic is also in action on Court 17 up against Uruguay's Pablo Cuevas.
Then Radwanska, Kirsten Flipkens, Venus Williams, Serena Williams, Francesca Schiavone, Jelena Jankovic, Madison Keys, Angelique Kerber, Jamie Hampton, Laura Robson and Sabine Lisicki are also among the stars of the women's game in action as well.
World No. 3 Pole Radwanska opens up proceedings on Arthur Ashe Stadium when she takes on Spaniard Silvia Soler-Espinosa.
Venus Williams will then follow that match in what could potentially be the last US Open, and Grand Slam tournament, for the 33-year-old seven-time major winner.
However, the elder Williams sister will have a big task getting through to the second round when she faces the No. 12 seed Belgian Flipkens.
Venus' younger sister Serena will then open proceedings for evening session when the world No. 1 takes on Italian veteran Schiavone.
Serena is searching for her 17th Grand Slam title and second of this year after winning at Roland Garros but the 31-year-old Schiavone will be a tricky opponent with all her experience and history of winning the 2010 French Open and six WTA titles in her career.
Former world No. 1 and the ninth-seed for this year's US Open Jankovic also faces a tricky task of entering the second round when the Serb takes on exciting young American Keys in the third match of the day on the Grandstand court.
That match will be followed up by the eighth-seeded German Kerber taking on Czech Lucie Hradecka.
Romanian No. 19 seed Sorana Cirstea also takes on Canadian Sharon Fichman while later on the same Court 6 Russian Ekaterina Makarova takes on Slovakia's Polona Hercog.
Court 10 will see another fascinating battle between Russian 32nd-seed Anastasia Pavlyuchenkova and French veteran Virginie Razzano.
Women's action on Louis Armstrong Stadium also sees two exciting encounters featuring China's Li Na up against Belarusian Olga Govortsova and later American No. 15 seed Sloane Stephens taking on Luxembourg's Mandy Minella.
German No. 16 seed Lisicki, who made the Wimbledon final earlier this year, might be relegated to Court 13 but will be looking to make a strong start against Russian Vera Dushevina.
Another American youngster Hampton, the 23rd-seed, is also in action on Court 17 when she takes on Spain's Lara Arruabarrena.