Trengove will play his first pre-season match for Melbourne's reserve team Casey Scorpions - a VFL practice hitout against Port Melbourne.
The 21-year-old Demons co-captain has had a curtailed pre-season because of a foot stress fracture discovered in early December.
But having undergone painstaking rehabilitation and training hard without playing, Trengove is hoping his patience will be rewarded with a pain-free hitout.
"The way we have worked the training program is that I'd be ready to go round one. Obviously there's a few boxes I have to tick," Trengove said.
"There's this weekend playing my first trial game for the season. It'll all depend on how I go in that game.
"I'm feeling really fit and ready to go, and hopefully I can have a big year myself."
Trengove will be joined in the reserves hitout by his rehab shadow Mitch Clark, who suffered a more serious foot fracture midway through last AFL season.
The 25-year-old forward is also on track for round one selection if he comes through the match unscathed.
"Clarky's in a similar position to me. He's coming off a more serious injury, but our timing's been about the same," Trengove said.
"He's down to play this weekend. All going well this weekend, he'll be right to play in round one as well."
Trengove admits the Demons' round one clash with Port Adelaide the following weekend will be an important marker for the season ahead.
The Demons were flogged in last year's season opener by Brisbane, and struggled badly for the rest of 2012.
Port also had a difficult last season, and both clubs appear to be at a similar stage of rebuilding.
"Especially a team that people say are around a similar position to you, you really want to be getting on top of them," Trengove said.
"It's going to be a great challenge. It would be great to start the year off with a win to take us into a big season."