Clarke hobbled off with a leg injury, but it's not yet known how serious the injury is.
Should Clarke be ruled out, it would be a huge blow for the Dockers, who will also be without ruckman Aaron Sandilands for the derby due to a torn hamstring.
Jon Griffin will lead the ruck battle against West Coast, while Kepler Bradley is a chance to earn a call-up if Clarke fails to play.
West Coast also have a decision to make in the ruck department after Nic Naitanui failed in his bid to be fit for the season opener.
If the Eagles decide Dean Cox needs back-up in the ruck, either Scott Lycett or Callum Sinclair will be called into the side.
West Coast will also be without midfielder Daniel Kerr (knee), forward Mark Nicoski (hamstring), wingman Matt Rosa (quad) and former 'Pie Sharrod Wellingham (ankle).