The NRL on Thursday afternoon released a statement to allay fears the Sharks could be headed for a forfeit while doping investigations are carried out.
As many as 14 Cronulla players have been warned to take six-month suspensions as a result of the probe, which stems from an Australian Crime Commission report in February.
But on the eve of the opening round of the season, NRL chief executive David Smith said he understood the uncertainty that supporters of the Sharks must feel.
“With the season kick-off just hours away we accept that the ongoing speculation around the ASADA investigation is causing incredible uncertainty for many in the game, particularly right now for Cronulla and its fans,” Smith said in an NRL statement.
“As I have said from day one, the NRL is taking the ASADA investigation very seriously.
“It is an investigation that must be allowed to run its course and it is inappropriate for us to enter into speculation about what may be taking place.
“Let me make it very clear, however, the absolute majority of our players - the absolute majority - are doing the right thing. They are great ambassadors for the game, on and off the field as we will see at Allianz Stadium this evening."