Australia scored 7-259 after winning the toss and dismissed West Indies for 144 in the 44th over.
Pace bowler Perry (3-19 off 10 overs) ripped through the top order, taking 3-2 in a 10-ball spell.
Perry,who missed Australia's last three games through illness and injury, also delivered with the bat.
She combined with captain Jodie Fields in an unbroken stand of 50 off 40 balls, that boosted the side from a parlous position of 7-209, after the Southern Stars lost 4-28.
Hard-hitting Victorian Jess Cameron (75 off 76) again proved she was a big occasion player after topscoring in Australia's World T20 final win last October.
Openers Meg Lanning (31 off 41) and Rachael Haynes (52 off 74) set the platform with a stand of 52 off 10 overs.
Perry and allrounder Sarah Coyte were recalled to the Australian side after recovering from injury, replacing 17-year-old speedster Holly Ferling and Renee Chappell.
Drama enveloped Perry even before she bowled her first delivery.
Twice she pulled out before reaching the crease, sending a shiver through Australian supporters, who feared the ankle injury that kept her out of the last two games had not healed.
While she didn't appear to be walking freely, Perry quickly dispelled worries about her health with a match-titling spell.
She trapped Kycia Knight (17 off 35) with the final ball of her first over to end a 32-run opening stand off ten overs.
Off the first ball of her second over, she appeared to have star batter Stafanie Taylor caught in the slips by Meg Lanning, but the third umpire couldn't confirm the ball had carried.
Perry didn't require assistance three balls later when she took a simple return catch to remove Taylor (5 off 9).
The Australian football international struck again in her third over earning an lbw decision against opener Natasha McLean (13 off 30).
Veteran allrounder Lisa Sthalekar (2-20 off 10) was Australia's other bowling hero.
The clever spinner outfoxed West Indies captain Merrisa Aguilleira (23 off 46) and powerful hitter Deandra Dottin (22 off 28).
Both were looking dangerous, with Dottin smashing two sixes and Aguilleira one, but Sthalekar bowled both to leave West Indies 5-109 in the 31st over.
West Indies quickly slumped to 8-114.
Megan Schutt (2-38 off 10) struck twice to finish he tournament's leading wicket taker with 15.
Schutt, spinner Erin Osborne (2-26 off 7) and opening bowler Julie Hunter (1-18 off 4.1) swept through the bottom half of the order.