In reply to the West Indies' total of 220 that was a competitive total at least thanks to an unbeaten 109 from Kieron Pollard after the tourists were 6-55, Australia cruised to end up 5-221 in just 44.5 overs.
Shane Watson top-scored for Australia with another impressive opening knock of 76 from 84 to back up his century from Wednesday to show that he very well could be ready to do the job in the Test team in India.
With Aaron Finch also making 25, Phil Hughes 23, Michael Clarke 37, Adam Voges 28 and Matthew Wade an unbeaten 13, the Aussies made steady progress right the way through to take a 4-0 lead in the five-match series that ends at the MCG on Sunday.
Finch again made a solid start but couldn’t go on with it after he was out LBW from the spin of Sunil Narine for 25 from 30 deliveries.
The home side was then 1-53 with Watson joined at the crease by Hughes with the pair coming off a tremendous stand together in Canberra on Wednesday.
Watson has survived two scares on his way to a half-century firstly being dropped by wicket-keeper Devon Thomas off Dwayne Bravo and then just avoiding being run out, but the pair's luck eventually ran out.
Hughes fell for 23 when caught at slip by Dwayne Bravo off Narine after attempting a sweep and misjudging it to hit it off his toe-end to slip.
Australia was 2-115 with Clarke joining Watson and the pair added 30 before Watson's luck ran out when he was caught behind for 76 off Tino Best.
Voges and Clarke then added 53 before Voges fell for 28 before Clarke fell with the scores level for 28. Glenn Maxwell came in and hit the winning runs.
Narine was the pick of the West Indies' bowlers with the spinner taking 2-34 from 10 overs. Best also claimed 2-38 in a fiery 9.5 overs.
Earlier, the West Indies made a disastrous start to its innings with Chris Gayle not taking his place in the side due to his side strain.
Kieran Powell made just nine, Johnson Charles a duck, Darren Bravo four, Dwayne Bravo three, Narsingh Deonarine 10 and Devon Thomas seven as the West Indies fell to 6-55 after 20 overs.
Sammy offered Pollard some support making 25 with Andre Russell also scoring 18 and Narine 23 to help the West Indies at least make a competitive total.
Mitchell Johnson was the early star with the ball for Australia and finished with 3-36 from 10 overs.
Ben Cutting also took 3-45 from 10 with Clint McKay, Maxwell and James Faulkner all picking up a wicket apiece.