Sharapova, 25, cruised through the match 6-2, 6-2 in just over an hour to set up a semi-final showdown with China's Li Na on Thursday.
The Russian star had dropped just nine games in five matches so far in this tournament in advancing to her semi-final.
It is the least number of games conceded by a player at the Australian Open in the modern era.
It beats the previous record of 12 games set by Monica Seles back in 1991.
"Today was a matter of being focused because she's been playing great and this is her second grand slam quarter-final and I know she was excited to play me," Sharapova said.
Radwanska went into the clash on the back of a run of 13 consecutive match wins, taking out titles in Auckland and Sydney, where Li Na lost to the Polish player.
Sharapova, ranked number two in the world, was ruthless after surviving somewhat of a slow start when at 2-2 and especialliy with a more dominant second set to comfortably seal the match.
Sharapova has been in startling form as the four times Grand Slam tournament winner continues a full comeback from shoulder problems and surgery late last year.
The number two seed for this tournament confronts Li Na, who is sixth seed, after she had to battle through her quarter-final earlier in the day to topple Agnieszka Radwanska 7-5, 6-3.