Hussey, 37, made an emotional farewell to the international playing arena after Australia's Third Test and series win over Sri Lanka in Sydney early this month.
He was confirmed as a starter in Wednesday's knockout semi-final against Warne's Melbourne Stars when Scorchers management made just one change to their starting line-up.
Warne's undermanned unit has been denied access to national one-day specialists David Hussey, Clint McKay, Glenn Maxwell and wicketkeeper-batsman Matthew Wade by Australian cricket authorities.
Warne and his outfit are also without dangerous paceman Lasith Malinga with his international commitments with Sri Lanka.
Malinga demolished Perth at their last outing at the WACA when he grabbed an historic 6-7 and bundled the Scorchers ot for just 69.
Hussey replaces seam specialist Joe Mennie in Perth's 13-man squad.
Perth's squad is: Simon Katich (Captain), Michael Beer, Jason Behrendorff, Hilton Cartwright, Nathan Coulter-Nile, Herschelle Gibbs, Brad Hogg, Mike Hussey, Shaun Marsh, Marcus North, Alfonso Thomas, Tom Triffitt, Adam Voges.
Perth have won five of their last six games to snatch second spot on the BBL ladder and a home semi-final.
Hussey played the opening match of the Scorchers Big Bash program back on December 9 when the brilliant left-hander managed just four.
The Test and limited-overs top-order specialist is tipped to bat at number three in the Scorchers outfit.
Former Test batsman Marcus North looms as the Scorcher likely to lose his spot for Hussey.
Scorchers coach Justin Langer welcomed the return of such an all-round batting talent and experienced veteran like Hussey.
“It’s rare that you have the opportunity to bring a player of the calibre of Mike Hussey into a winning team," Langer said on releasing his squad.
"He is one of the world’s best T20 players and adds enormous depth and talent to our line-up.
“It is always hard to change a winning combination but the business we are in is to pick the best possible combination to win this semi final. If we are able to achieve that then everyone in the squad will gain a benefit in the future.
“We were humbled by the Stars when they last played us at The Furnace so we will certainly be treating them with great respect, but I am confident our preparation and the style of cricket we have been playing will hold us in good stead for tomorrow night’s game.”