Malinga's tally of 13 wickets at 10.69 places him on top of the wicket-taking table in the Big Bash League this summer alongside Hobart Hurricanes' Ben Laughlin.
"All our batters have to really get down to business and do their homework and really try to take him (Malinga) out of the equation," Hussey told a media conference on Wednesday.
Hussey knows the ODI series against Sri Lanka then West Indies present him with opportunities to push his case for a possible Test debut in India in February.
The 35-year-old also knows runs against the frightening pace of Malinga will stack up well in the selectors' eyes, starting with Friday's game at the MCG.
"Never scared - it's always exciting," said Hussey, whose chances of a Test debut have improved following the sudden retirement of his older brother Mike earlier this month.
"You always want to play the best bowlers in the world. It's a great opportunity to face him (Malinga).
"If you do well against him, it gives not only your team a lot of confidence but yourself and your game a lot of confidence as well.
"Everyone has talked about replacing Mike in the Test squad.
"I just want to do well and contribute to the (ODI) team's success and hopefully win a series against Sri Lanka.
"That's all I'm really focusing on and having no regrets."
David Hussey struggled in his most recent ODI series when he scored 46 runs at 15.33 in three matches against Pakistan in the United Arab Emirates in August and September 2012.
"A few times I've played for Australia in the past, I've had a few regrets and didn't really play the way I wanted to play," Hussey said.
"This time, fresh mind, new opportunity and play with no regrets."
Hussey said he couldn't even dream of emulating Mike Hussey's performances as Australia's late-innings pace-setter.
"A few people are going to put their hands up for that finishing role," David Hussey said.
"I've had a couple of (attempts) at it and have struggled with it so I really need to stamp my authority and do it consistently well.
"Maybe not quite as well as Mike's done it. Maybe do it half as well as him and I can contribute to team success."